General
Preferred name
APHIDICOLIN
Synonyms
(+)-Aphidicolin ()
P&D ID
PD041796
CAS
38966-21-1
Tags
available
drug candidate
nuisance
Drug Status
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Aphidicolin is an inhibitor of DNA polymerase ¦Á and ¦Ä, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line[1][2][3].
Cell lines
4
Organisms
1
Compound Sets
9
Cayman Chemical Bioactives
14007
Drug Repurposing Hub
DrugBank
DB17742
DrugMAP
DM71C6D
MedChem Express Bioactive Compound Library
HY-N6733
Novartis Chemogenetic Library (NIBR MoA Box)
Nuisance compounds in cellular assays
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
ReFrame library
External IDs
36
Properties
(calculated by RDKit )
Molecular Weight
338.25
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
2.09
TPSA
80.92
Fraction CSP3
1.0
Chiral centers
8.0
Largest ring
6.0
QED
0.62
Structural alerts
1
Genotoxic
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
Inhibitor of DNA polymerase alpha
DNA polymerase alpha inhibitor
RNA synthesis inhibitor
Cellular injury category
Genotoxin
Target
antibiotic
Apoptosis
DNA/RNA Synthesis
HSV
Orthopoxvirus
Pathway
Anti-infection
Cell Cycle/DNA Damage
Source data