General
Preferred name
NSC-17102
Synonyms
4-Androsten-11β-ol-3,17-dione ()
4-Androsten-11¦Â-ol-3,17-dione ()
11-Beta-hydroxyandrostenedione ()
4-Androsten-11?-ol-3,17-dione ()
P&D ID
PD041610
CAS
382-44-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 11-Beta-hydroxyandrostenedione (4-Androsten-11¦Â-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11¦Â-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11¦Â-hydroxysteroid dehydrogenase (11¦ÂHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism[1][2].
PRICE 44
DESCRIPTION 11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11??-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11??-hydroxysteroid dehydrogenase isozymes inhibitor. Measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism with 4-androstenedione increases.
DESCRIPTION 11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. Measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism with 4-androstenedione increases. (TargetMol Bioactive Compound Library)
Compound Sets
4
Cayman Chemical Bioactives
30410
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
HY-114464
TargetMol Bioactive Compound Library
T14001
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
302.19
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
0
cLogP
3.06
TPSA
54.37
Fraction CSP3
0.79
Chiral centers
6.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
11β-HSD
Endogenous Metabolite
Human Endogenous Metabolite
11¦Â-HSD
MOA
steroid
Pathway
Metabolic Enzyme/Protease
Metabolism
Source data