General
Preferred name
FM19G11
Synonyms
HIF-1alpha/2alpha Inhibitor ()
P&D ID
PD041117
CAS
329932-55-0
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1¦Á) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC50 of 80 nM in HeLa cells. FM19G11 modulates other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1¦Á pathway is inactivated under normoxic conditions[1][2].
PRICE 166
DESCRIPTION FM19G11 is an inhibitor of hypoxia inducible factor (HIF) ??-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).
DESCRIPTION FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay). (TargetMol Bioactive Compound Library)
DESCRIPTION Enhances reprogramming to pluripotency; facilitates telomere maintenance and increases telomere length (Tocris Bioactive Compound Library)
Compound Sets
5
Axon Medchem Screening Library
2959
MedChem Express Bioactive Compound Library
HY-15672
Selleckchem Bioactive Compound Library
fm19g11
TargetMol Bioactive Compound Library
T36711
Tocris Bioactive Compound Library
6653
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
463.1
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
3
cLogP
4.1
TPSA
158.75
Fraction CSP3
0.09
Chiral centers
0.0
Largest ring
6.0
QED
0.23
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Custom attributes
(extracted from source data)
Target
HIF-1α
HIFa inhibitor
HIF/HIF Prolyl-Hydroxylase
HIF
Primary Target
Hypoxia Inducible Factors (HIF)
MOA
Inhibitor
Pathway
Angiogenesis
Chromatin/Epigenetic
Metabolic Enzyme/Protease
Source data