General
Preferred name
MMPIP
Synonyms
MMPIP hydrochloride (479077-02-6 Free base) ()
MMPIP hydrochloride ()
MMPIP (hydrochloride) ()
P&D ID
PD040949
CAS
1215566-78-1
479077-02-6
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
MMPIP hydrochloride is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (KB values 24 -30 nM). MMPIP hydrochloride acts as a pharmacological tool for elucidating the roles of mGluR7 on central nervous system functions. MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice[1][2].
PRICE
168
DESCRIPTION
alpha1 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
MMPIP is a reversible allosteric antagonist of the metabotropic glutamate receptor 7 (mGluR7) that blocks agonist-induced calcium mobilization (IC50 = 26 nM). It was demonstrated to reduce pain responses and affective/cognitive impairments in neuropathic pain conditions.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system functions.
(TargetMol Bioactive Compound Library)
DESCRIPTION
MMPIP hydrochloride is a potent, selective, allosteric antagonist of metabotropic glutamate receptor 7 (mGluR7). It inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 = 26 and 610 nM). MMPIP also exhibits intrinsic activity and acts as an inverse agonist.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
333.11
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
4
cLogP
3.26
TPSA
70.15
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
mGlu7
mGluR
Primary Target
Glutamate (Metabotropic) Group III Receptors
MOA
Modulator
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Solubility
DMSO to 10 mM
Source data
