General
Preferred name
MELDONIUM
Synonyms
Kvaterin ()
Quaterin ()
Mildronate ()
Meldonium (dihydrate) ()
MET-88 ()
MET-88 (dihydrate) ()
Quaterin (dihydrate) ()
Mildronate dihydrate ()
Meldonio ()
Quaterine ()
Mildronate (hydrate) ()
P&D ID
PD040924
CAS
76144-81-5
802032-35-5
86426-17-7
Tags
available
drug
Drug Status
investigational
approved
Max Phase
2.0
Drug indication
Cardiovascular disease
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Mildronate dihydrate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.
PRICE
29
DESCRIPTION
Meldonium functions as a cardioprotective drug by competitively inhibiting gamma-butyrobetaine dioxygenase (BBOX1) and SLC22A5 (OCTN2).
(Enamine Bioactive Compounds)
DESCRIPTION
Mildronate (Meldonium) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
49
Molecular Weight
146.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.66
TPSA
52.16
Fraction CSP3
0.83
Chiral centers
0.0
Largest ring
0.0
QED
0.38
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Dopamine β-hydroxylase
Dopamine ¦Â-hydroxylase
Mitochondrial Metabolism
MOA
Hydroxylase inhibitor
Pathway
Metabolic Enzyme/Protease
Metabolism
Source data
