General
Preferred name
H-7 DIHYDROCHLORIDE
Synonyms
1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride ()
5-(2-methylpiperazine-1-sulfonyl)isoquinoline ()
Protein kinase inhibitor H-7 (dihydrochloride) ()
5-(2-methylpiperazin-1-ylsulfonyl)isoquinoline ()
Protein kinase inhibitor H-7 ()
H-7 (hydrochloride) ()
P&D ID
PD040813
CAS
108930-17-2
84477-87-2
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Inhibitor of cyclic nucleotide dependent protein kinase (PKA) and protein kinase C (PKC)
(LOPAC library)
DESCRIPTION
LTB omega-hydroxylase inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
H-7 dihydrochloride is a protein kinase inhibitor (IC50 = 6.0, 5.8, 3.0 and 97.0 μM for inhibition of PKC, PKG, PKA and myosin light chain kinase, respectively). H-7 inhibits cell invasion and metastasis in B16BL6 cancer cells through the PKC/MEK/ERK pathway. It was also shown to inhibit Topo I and II in murine L929 cells and induce apoptosis via PKC inhibition.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
8
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
291.1
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
1.22
TPSA
62.3
Fraction CSP3
0.36
Chiral centers
1.0
Largest ring
6.0
QED
0.9
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
PKA / PKC
Primary Target
Broad Spectrum Protein Kinase Inhibitors
MOA
Inhibitor
Pathway
Epigenetics
TGF-beta/Smad
Target
PKC
Source data
