General
Preferred name
DIDS
Synonyms
4,4'-DIISOTHIOCYANOSTILBENE-2,2'-SUFONIC ACID SODIUM SALT ()
MDL101114ZA ()
DIDS sodium salt ()
DIDS disodium salt ()
P&D ID
PD040631
CAS
67483-13-0
53005-05-3
152216-76-7
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
High affinity 5-HT3 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
DIDS disodium salt is a stilbene sulfonate that acts as a ClC-Ka chloride channel blocker (IC50 = 100 μM). It blocks the maxi chloride channel in apical membranes from human placenta to inhibit the Cl- uptake. DIDS also has antagonistic activity at TRPM4 and TRPC4 channels.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
4
BOC Sciences Bioactive Compounds
DrugMAP
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
48
Molecular Weight
453.94
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
3.82
TPSA
133.46
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.29
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Target
ABCA1
VDAC1
Primary Target
Other Chloride Channels
MOA
Blocker
Source data
