General
Preferred name
oleandrin
Synonyms
Neriostene ()
Folinerin ()
Foliandrin ()
PBI-05204 ()
Foliandrin, Neriolin, Neriostene, Folinerin, Corrigen, Neriol ()
Oleandrin (PBI-05204) ()
NSC-692219 ()
Anvirzel ()
P&D ID
PD040549
CAS
465-16-7
Tags
available
drug
natural product
Drug indication
Pancreatic cancer
Lung cancer
Solid tumour/cancer
Drug Status
approved
experimental
investigational
Max Phase
1.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Oleandrin (PBI-05204) inhibits the Na+, K+-ATPase activity with an IC50 of 620 nM.
PRICE
493
DESCRIPTION
Oleandrin is a plant-derived glycoside. It has been associated with a range of biological effects in animals , including potential anti-tumour activity . Inhibition of FGF-2 export from prostate cancer cells has been reported, and this is proposed as a potential mechanism underlying its anti-tumour effect .
(GtoPdb)
DESCRIPTION
1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, K-ATPase pump, resulting in a consequent increase in calcium influx in heart muscle. 3. Oleandrin has stronger anti-proliferative activity in undifferentiated CaCO-2 cells (IC50, 8.25 nM) , causes an autophagic cell death and altered ERK phosphorylation in undifferentiated.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
8
Organisms
0
Compound Sets
12
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
576.33
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
6
Aromatic Ring Count
0
cLogP
3.68
TPSA
120.75
Fraction CSP3
0.88
Chiral centers
13.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Na+/K+ ATPase
Potassium Channel
Sodium Channel
ATPase
MOA
Na/K-ATPase inhibitor
Pathway
Membrane Transporter/Ion Channel
Source data
