General
Preferred name
PHENYLARSINE OXIDE
Synonyms
Oxophenylarsine ()
PhAsO ()
Arsenosobenzene ()
Phenylarsine Oxide ()
P&D ID
PD040505
CAS
637-03-6
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Phenylarsine oxide (PAO), an inhibitor of endocytosis, inhibits PTP¦Å with an IC50 of 18 ¦ÌM. Phenylarsine oxide (PAO) inhibits oxygen consumption and decreases cellular ATP content overlap with those used to inhibit protein internalization[1][2].
DESCRIPTION PAO inhibits type III PI 4-kinases, whereas it is relatively ineffective against the type II in in vitro kinase assays. Among the type III enzymes, PI4KIIIα is significantly more sensitive to PAO than the type IIIβ form . (GtoPdb)
Cell lines
2
Organisms
1
Compound Sets
4
Cayman Chemical Bioactives
35525
Guide to Pharmacology
9201
MedChem Express Bioactive Compound Library
HY-131901
Selleckchem Bioactive Compound Library
phenylarsine-oxide
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
167.96
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
0.36
TPSA
17.07
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
phosphatase
Pathway
Metabolic Enzyme/Protease
Source data