General
Preferred name
FOROPAFANT
Synonyms
SR27417 ()
SR-27417 ()
P&D ID
PD040285
CAS
136468-36-5
Tags
available
drug candidate
Drug indication
Asthma
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1].
PRICE 178
DESCRIPTION Foropafant (SR27417) is a highly potent and selective platelet-activating factor (PAF) receptor antagonist (Ki: 57 pM). Foropafant potently inhibits the PAF-induced aggregation of rabbit and human platelets. (TargetMol Bioactive Compound Library)
Compound Sets
12
ChEMBL Drugs
CHEMBL1628662
Concise Guide to Pharmacology 2017/18
1856
Concise Guide to Pharmacology 2019/20
1856
Concise Guide to Pharmacology 2021/22
1856
Concise Guide to Pharmacology 2023/24
1856
Drug Repurposing Hub
DrugMAP
DML1DGP
DrugMatrix
Guide to Pharmacology
1856
MedChem Express Bioactive Compound Library
HY-128694
ReFrame library
TargetMol Bioactive Compound Library
T15338
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
464.3
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
10
Ring Count
3
Aromatic Ring Count
3
cLogP
7.14
TPSA
32.26
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.32
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
platelet-activating factor (PAF)
PTAFR
Platelet-activating Factor Receptor (PAFR)
MOA
Platelet activating factor receptor antagonist
Pathway
GPCR/G protein
Source data