General
Preferred name
BMS 753
Synonyms
BMS753 ()
P&D ID
PD040105
CAS
215307-86-1
Tags
drug candidate
available
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION BMS 753 is an isotype-selective retinoic acid receptor ¦Á (RAR¦Á) agonist, with a Ki of 2 nM[1].
PRICE 73
DESCRIPTION BMS 753 is an agonist of isotype-selective retinoic acid receptor ?? (RAR??, Ki= 2 nM).
DESCRIPTION BMS 753 is a RARα-selective agonist (Ki = 2 nM) that modulates the ATRA-inducible cytochrome P450 26A1 (CYP26A1). (BOC Sciences Bioactive Compounds)
DESCRIPTION BMS 753 is an agonist of isotype-selective retinoic acid receptor α (RARα, Ki= 2 nM). (TargetMol Bioactive Compound Library)
DESCRIPTION RARalpha agonist; anticancer agent (Tocris Bioactive Compound Library)
Compound Sets
13
BOC Sciences Bioactive Compounds
bms-753-cas-215307-86-1-item-119113
Cayman Chemical Bioactives
29493
Concise Guide to Pharmacology 2017/18
2650
Concise Guide to Pharmacology 2019/20
2650
Concise Guide to Pharmacology 2021/22
2650
Concise Guide to Pharmacology 2023/24
2650
CZ-OPENSCREEN Bioactive Library
DrugMAP
DMSX1NF
EUbOPEN Chemogenomics Library
EUB0000565
Guide to Pharmacology
2650
MedChem Express Bioactive Compound Library
HY-107395
TargetMol Bioactive Compound Library
T22049
Tocris Bioactive Compound Library
3505
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
351.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
3.78
TPSA
83.47
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
RARα
RAR/RXR
Primary Target
Retinoic Acid Receptors
MOA
Agonist
Pathway
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Metabolism
Recommended Cell Concentration
1 uM
Source data