General
Preferred name
PF-06273340
Synonyms
PF 06273340 ()
PF06273340 ()
P&D ID
PD039926
CAS
1402438-74-7
Tags
available
drug candidate
Drug Status
investigational
Max Phase
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Potent and selective heme oxygenase 1 (HO-1) inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION PF 06273340 is a potent and selective, orally bioavailable pan-Trk kinase inhibitor with IC50 of 6, 2, and 1 nM for Trk A, B and C, respectively. PF 06273340 is selective for Trk over a panel of ion channels, receptors and other enzymes. It shows efficacy in a rodent model of inflammatory pain. (BOC Sciences Bioactive Compounds)
Compound Sets
8
BOC Sciences Bioactive Compounds
pf-06273340-cas-1402438-74-7-item-170258
ChEMBL Drugs
CHEMBL4212531
Drug Repurposing Hub
DrugBank
DB12269
MedChem Express Bioactive Compound Library
HY-122616
ReFrame library
Selleckchem Bioactive Compound Library
pf-06273340
Tocris Bioactive Compound Library
6115
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
479.15
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
4
cLogP
2.6
TPSA
148.91
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.34
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Primary Target
Trk Receptors
MOA
Inhibitor
tyrosine kinase receptor inhibitor
Pathway
Neuronal Signaling
Protein Tyrosine Kinase/RTK
Target
Trk Receptor
Source data