General
Preferred name
L-Homoserine
Synonyms
(2S)-2-Amino-4-hydroxybutanoic acid ()
L-Hse ()
Isothreonine ()
HOMOSERINE ()
P&D ID
PD039917
CAS
498-19-1
1927-25-9
672-15-1
Tags
available
drug candidate
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION L-Homoserine is a nonessential chiral amino acid and the precursor of L-Threonine (HY-N0658) and L-Methionine (HY-N0326). L-Homoserine wide applications in the fields of pharmaceutical, agricultural, cosmetic and fragrance industries[1].
PRICE 29
DESCRIPTION L-Homoserine ((S)-(-)-2-AMINO-4-HYDROXYBUTYRIC ACID) is a more reactive variant of the amino acid serine. In this variant, the hydroxyl side chain contains an additional CH2 group which brings the hydroxyl group closer to its own carboxyl group, allowing it to chemically react to form a five-membered ring. This occurs at the point that amino acids normally join to their neighbours in a peptide bond. L-Homoserine is therefore unsuitable for forming proteins and has been eliminated from the repertoire of amino acids used by living things. L-Homoserine is the final product on the C-terminal end of the N-terminal fragment following a cyanogen bromide cleavage.
Compound Sets
4
DrugBank
DB04193
Enamine Bioactive Compounds
EBC-48150
MedChem Express Bioactive Compound Library
HY-W002292
Selleckchem Bioactive Compound Library
l-homoserine
External IDs
67
Properties
(calculated by RDKit )
Molecular Weight
119.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.22
TPSA
83.55
Fraction CSP3
0.75
Chiral centers
1.0
Largest ring
0.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
Pathway
Metabolic Enzyme/Protease
Source data