General
Preferred name
(S)-SNAP 5114
Synonyms
SNAP-5114 ()
(S)-SNAP5114 ()
P&D ID
PD039766
CAS
157604-55-2
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION (S)-SNAP5114 is a selective GABA transport inhibitor, with IC50 values of 5 ¦ÌM and 21 ¦ÌM for hGAT-3 and rGAT-2, respectively. (S)-SNAP5114 is an anticonvulsant agent[1][2].
PRICE 119
DESCRIPTION (S)-SNAP5114 is a selective inhibitor of GABA transport, exhibiting IC50 values of 5 ??M for hGAT-3 and 21 ??M for rGAT-2, and possesses anticonvulsant properties.
DESCRIPTION (S)-SNAP 5114 is a GABA transport inhibitor, displaying selectivity for GAT-3 and GAT-2 (IC50 = 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1, respectively). (S)-SNAP 5114 was shown to increase thalamic GABA levels, and acts as an anticonvulsant following systemic administration in vivo. (BOC Sciences Bioactive Compounds)
DESCRIPTION (S)-SNAP5114 is a selective inhibitor of GABA transport, exhibiting IC50 values of 5 μM for hGAT-3 and 21 μM for rGAT-2, and possesses anticonvulsant properties. (TargetMol Bioactive Compound Library)
DESCRIPTION Potent 5-HT uptake inhibitor; also inhibits dopamine and noradrenalin uptake (Tocris Bioactive Compound Library)
Compound Sets
10
BOC Sciences Bioactive Compounds
s-snap-5114-cas-157604-55-2-363538
Concise Guide to Pharmacology 2017/18
4677
Concise Guide to Pharmacology 2019/20
4677
Concise Guide to Pharmacology 2021/22
4677
Concise Guide to Pharmacology 2023/24
4677
DrugMAP
DMFM19S
Guide to Pharmacology
4677
MedChem Express Bioactive Compound Library
HY-103504
TargetMol Bioactive Compound Library
T16831
Tocris Bioactive Compound Library
1561
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
505.25
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
11
Ring Count
4
Aromatic Ring Count
3
cLogP
4.82
TPSA
77.46
Fraction CSP3
0.37
Chiral centers
1.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
GAT-2
GAT-3
GABA Receptor
Primary Target
GABA Transporters
MOA
Inhibitor
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Neuroscience
Source data