General
Preferred name
PD039600
Synonyms
3'-Guanylic acid, adenylyl-(3'?5')-, cyclic nucleotide ()
2'3'-cGAMP (sodium salt) ()
2'3'-cGAMP ()
2'3'-cGAMP-d8 (ammonium salt) ()
P&D ID
PD039600
CAS
2734858-36-5
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
2'3'-cGAMP is produced in mammalian cells by the action of cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) upon detection of double-stranded DNA in the cytosol that originates for example, from tumours or viruses. It is the endogenous agonist of the human STING protein , but appears not to activate mouse Sting. STING activation at the endoplasmic reticulum triggers type-I IFNs production by the innate immune response .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
674.1
Hydrogen Bond Acceptors
20
Hydrogen Bond Donors
7
Rotatable Bonds
2
Ring Count
7
Aromatic Ring Count
4
cLogP
-2.34
TPSA
329.65
Fraction CSP3
0.5
Chiral centers
10.0
Largest ring
13.0
QED
0.11
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
