General
Preferred name
MLS1547
Synonyms
MLS000051547 ()
MLS 1547 ()
MLS-1547 ()
P&D ID
PD039572
CAS
315698-36-3
Tags
available
drug candidate
biased GPCR ligand
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION MLS1547 is a highly efficacious G protein-biased dopamine D2 receptor (D2R) agonist (Ki=1.2 ¦ÌM). MLS1547 stimulates D2R G protein-mediated signaling (EC50=0.37 ¦ÌM in a calcium mobilization assay). MLS1547 acts as an antagonist for dopamine (DA)-stimulated ¦Â-arrestin recruitment to the D2R (IC50=9.9 ¦ÌM)[1][2].
DESCRIPTION MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 ??M. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 ??M in a calcium mobilization assay.
DESCRIPTION MLS1547 is reported to be a G protein biased dopamine D2 receptor agonist . The compound antagonises arrestin recruitment to the dopamine-induced D2 receptor, but behaves as an agonist in its capacity to induce G protein signalling (ie inhibition of cAMP accumulation via Gi). (GtoPdb)
DESCRIPTION MLS 1547 is a dopamine D2 receptor agonist. It may be used in the combination with antipsychotic drugs. (BOC Sciences Bioactive Compounds)
DESCRIPTION MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay. (TargetMol Bioactive Compound Library)
DESCRIPTION Potent S1P receptor agonist; also immunosuppressant (Tocris Bioactive Compound Library)
Cell lines
5
Organisms
2
Compound Sets
13
BiasDB
MLS000051547
BOC Sciences Bioactive Compounds
mls-1547-cas-315698-36-3-item-169345
Cayman Chemical Bioactives
27648
Concise Guide to Pharmacology 2017/18
8369
Concise Guide to Pharmacology 2019/20
8369
Concise Guide to Pharmacology 2021/22
8369
Concise Guide to Pharmacology 2023/24
8369
DrugMAP
DMPTBJZ
EUbOPEN Chemogenomics Library
EUB0000921
Guide to Pharmacology
8369
MedChem Express Bioactive Compound Library
HY-128121
TargetMol Bioactive Compound Library
T28073
Tocris Bioactive Compound Library
6171
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
354.12
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
3.31
TPSA
52.49
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
D2 receptor
Dopamine Receptor
Primary Target
D2 Receptors
MOA
Agonist
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Recommended Cell Concentration
None
Source data