General
Preferred name
GV-58
Synonyms
P&D ID
PD039448
CAS
1402821-41-3
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GV-58 is a novel N- and P/Q-type calcium (Ca2+) channel agonist with EC50s of 7.21 and 8.81 ¦ÌM, respectively. GV-58 slows the deactivation of channels, resulting in a large increase in presynaptic Ca2+ entry during activity. GV-58 can be used in lambert-eaton myasthenic syndrome (LEMS) research[1][2][3].
PRICE 187
DESCRIPTION GV-58, a pupin derivative, has been found to be a P/Q-type Ca²⁺-channel agonist that could be used to against neuromuscular weakness. IC50: 7.21/8.81 uM (N-type/P-Q-type Ca2+ channel). (BOC Sciences Bioactive Compounds)
DESCRIPTION GV-58 is a selective N- and P/Q-type Ca2+ channels agonist (EC50: 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel). The inhibitory of GV-58 is 20-fold fewer for CDK kinases activity. (TargetMol Bioactive Compound Library)
Compound Sets
4
BOC Sciences Bioactive Compounds
gv-58-cas-1402821-41-3-item-474551
MedChem Express Bioactive Compound Library
HY-12498
Selleckchem Bioactive Compound Library
gv-58
TargetMol Bioactive Compound Library
T11517
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
374.19
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
3
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
3
cLogP
3.4
TPSA
87.89
Fraction CSP3
0.5
Chiral centers
1.0
Largest ring
6.0
QED
0.53
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Calcium Channel
N- and P/Q-type Ca2+ channels
N-type Ca2+ channel
P-Q-type Ca2+ channel
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Metabolism
Solubility
10 mM in DMSO
Source data