General
Preferred name
TAURODEOXYCHOLIC ACID
Synonyms
Taurodeoxychloic Acid (sodium hydrate) ()
Sodium taurodeoxycholate monohydrate ()
Taurodeoxychloic Acid sodium hydrate ()
Taurohyodeoxycholic acid sodium salt ()
Taurodeoxychloic acid ()
Taurodeoxycholate (sodium salt) ()
Taurodeoxycholic acid (sodium hydrate) ()
Sodium taurodeoxycholate (monohydrate) ()
Taurodeoxycholate sodium salt ()
Taurodeoxycholic acid sodium hydrate ()
Taurodeoxycholic Acid (sodium salt hydrate) ()
Tudcabil ()
Taurodesoxycholic acid ()
HY-209 ()
J339.140J ()
DEOXY CHOLATE ()
Hy209 ()
Deoxycholyltaurine ()
Taurodeoxycholic Acid MaxSpec® Standard ()
Taurodeoxycholic Acid-d4 (sodium salt) ()
Taurodeoxycholic Acid-d4 MaxSpec® Standard ()
Sodium taurodeoxycholate hydrate ()
P&D ID
PD039445
CAS
1180-95-6
516-50-7
110026-03-4
207737-97-1
1332881-65-8
2410279-82-0
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
atopic eczema
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Taurodeoxycholate sodium salt is a bile salt-related anionic detergent. Taurodeoxycholate sodium salt is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholate sodium salt is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) exhibits anti-inflammatory and neuroprotective effects[1][2][3][9][10].
DESCRIPTION
Taurodeoxycholate sodium salt is a bile salt-related anionic detergent. Taurodeoxycholic acid is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholic acid is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholic acid (TDCA) exhibits anti-inflammatory and neuroprotective effects[1][2][3][9][10].
PRICE
170
DESCRIPTION
Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. Taurodeoxycholic acid sodium hydrate activates the S1PR2 pathway in addition to the TGR5 pathway[1].
PRICE
31
PRICE
165
DESCRIPTION
Sodium taurodeoxycholate hydrate (Taurodeoxycholic acid sodium salt monohydrate) has been used in a study to assess the effect of submicellar concentrations of bile salts on the lipid bilayer membrane.
DESCRIPTION
Taurodeoxycholic acid (Taurodeoxychloic acid) is a bile acid taurine conjugate of deoxycholic acid, a human metabolite that stabilizes mitochondrial membranes and reduces the formation of free radicals.Taurodeoxycholic acid inhibits apoptosis by blocking calcium-mediated apoptotic pathways and by activation of caspase-12. Taurodeoxycholic acid has neuroprotective activity and has been used to study 3-nitropropionic acid-induced or stabilized hereditary Huntington's chorea (HD).
(TargetMol Bioactive Compound Library)
DESCRIPTION
Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a hydrophilic bile salt, influences bile salt and biliary lipid secretion in rats.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
ChEMBL Drugs
Other bioactive compounds
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
83
Molecular Weight
499.3
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
4
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
0
cLogP
3.4
TPSA
123.93
Fraction CSP3
0.96
Chiral centers
10.0
Largest ring
6.0
QED
0.4
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Caspase
Ca(2+) receptor
Endogenous Metabolite
G protein-coupled Bile Acid Receptor 1
NF-κB
PARP
PKA
S1PR Agonist
Pathway
Cell Cycle/DNA Damage
Epigenetics
GPCR/G protein
Metabolic Enzyme/Protease
Stem Cell/Wnt
TGF-beta/Smad
Proteases/Proteasome
Membrane Transporter/Ion Channel
Metabolism
NF-¦ÊB
Source data
