General
Preferred name
GUANINE
Synonyms
Guanine (hydrochloride) ()
2-Aminohypoxanthine ()
Valacyclovir hydrochloride, guanine- ()
C.i. no. 75170 (guanine) ()
Ci 75170 ()
Valganciclovir hydrochloride impurity b ()
Guanine-15N5 ()
P&D ID
PD039221
CAS
11006-44-3
73-40-5
635-39-2
168566-53-8
Tags
drug candidate
available
Drug Status
experimental
investigational
Max Phase
3.0
Drug indication
Cutaneous melanoma
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Guanine (2-Aminohypoxanthine) is a purine base that is a constituent of nucleotides occurring in nucleic acids.
DESCRIPTION
Guanine hydrochloride is one of the fundamental components of nucleic acids (DNA and RNA). It is a purine derivative composed of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine hydrochloride has the potential to serve as a large-capacity nitrogen reservoir[1].
DESCRIPTION
Guanine is an inhibitor of the Escherichia coli 6-oxopurine phosphoribosyltransferases.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
1
Compound Sets
11
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugMAP
Enamine Bioactive Compounds
Guide to Pharmacology
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
88
Molecular Weight
151.05
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
2
cLogP
-0.77
TPSA
100.45
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
DNA/RNA Synthesis
Endogenous Metabolite
Pathway
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Source data
