General
Preferred name
DIMEDAZOL
Synonyms
5,6-Dimethyl-1H-benzo[d]imidazole ()
5,6-DMB, Dimezol, Dimedazol, 5,6-Dimethyl-1H-benzo[d]imidazole, 5,6-Dimethyl-1H-benzimidazole ()
5,6-Dimethylbenzimidazole ()
P&D ID
PD039216
CAS
582-60-5
Tags
available
drug candidate
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 5,6-Dimethyl-1H-benzo[d]imidazole is an endogenous metabolite.
PRICE 29
DESCRIPTION 5,6-Dimethyl-1H-benzo[d]imidazole (5,6-Dimethylbenzimidazole) is an intermediate in Riboflavin metabolism and is the penultimate step in the synthesis of alpha-Ribazole. It is converted from Riboflavin and subsequently transformed into N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole by the enzyme nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21).
DESCRIPTION 5,6-Dimethylbenzimidazole is an endogenous metabolite. It inhibits Glutaminyl-peptide cyclotransferase (IC50 = 2.01 µM). (Enamine Bioactive Compounds)
Cell lines
2
Organisms
0
Compound Sets
5
Cayman Chemical Bioactives
36437
DrugBank
DB02591
Enamine Bioactive Compounds
EBC-14339
MedChem Express Bioactive Compound Library
HY-W017511
Selleckchem Bioactive Compound Library
5-6-dimethylbenzimidazole
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
146.08
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
2
cLogP
2.18
TPSA
28.68
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.61
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Drug intermediate
Endogenous Metabolite
Pathway
Metabolic Enzyme/Protease
Source data