General
Preferred name
CARBON MONOXIDE
Synonyms
CARBON MONOXIDE C 11 ()
Carbon oxide (co) ()
Carboneum oxygenisatum ()
Carbon-(sup 11)c monoxide ()
Carbon monoxide, c-11 ()
Carbon monoxide c-11 ()
Carbon (11c) monoxide ()
((sup 11)c)carbon monoxide ()
P&D ID
PD039106
CAS
153929-54-5
10456-04-9
Tags
drug candidate
drug
Drug Status
investigational
approved
Max Phase
Phase 3
Drug indication
Radioactive Agent
Diagnostic Aid (blood volume determination)
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
HALF-LIFE
The half-life of carbon monoxide at room air temperature is 3-4 hours. 100% oxygen reduces the half-life to 30-90 minutes; hyperbaric oxygen at 2.5 atm (atmosphere units) with 100% oxygen reduces it to 15-23 minutes [L2552].
ABSORPTION
Although CO is not one of the respiratory gases, the similarity of physico-chemical properties of CO and oxygen (O2) permits an extension of the findings of studies on the kinetics of transport of O2 to those of CO. The rate of formation and elimination of COHb, its concentration in blood, and its catabolism is controlled by numerous physical factors and physiological mechanisms [L2546]. ; ; The absorption of carbon monoxide from the consumption treated food products is not significant. Risk of CO toxicity from the packaging process or from consumption of CO-treated meats is negligible [A32745].
INDICATION
Used as a marker of respiratory status in spirometry tests [L2557], [F4].; ; Food additive for pigment fixation in meat [L2531].
PHARMACODYNAMICS
Carbon monoxide is used to measure the diffusing capacity for carbon monoxide (DLCO), also known as the transfer factor for carbon monoxide. It is a measure of the gas transfer from inspired gas to the circulatory system (red blood cells in particular) [L2557]. It is used in a particular pulmonary function test called "the single-breath test" [F5].; ; DLCO, measured for clinical and research purposes almost exclusively by the single-breath method is an important and very useful pulmonary function test. It is useful in the evaluation of patients with dyspnea, obstructive lung diseases, restrictive lung diseases, and in patients with diseases of the pulmonary vasculature. The measurement of DLCO using carbon monoxide is representative of the surface area available, the volume of blood present in the pulmonary capillaries, as well as the thickness of the alveolar-capillary membrane [F5].; ; ; **Conditions that increase DLCO:** Heart failure, erythrocythemia, alveolar hemorrhage, asthma; ; ; **Conditions that decrease DLCO:** emphysema, pulmonary fibrosis, pulmonary hypertension, pulmonary embolism; ; ; In addition to the above uses, carbon monoxide (CO) is increasingly being accepted in recent years as a protective molecule with important signaling capabilities in both physiological/homeostatic and pathophysiological situations. The endogenous production of CO occurs via the activity of constitutive (heme oxygenase 2) and inducible (heme oxygenase 1) heme oxygenase enzymes, which are both responsible for the breakdown of heme. Through the generation of its products, which in addition to carbon monoxide, includes the biliary pigments biliverdin, bilirubin and ferrous iron, the heme oxygenase 1 system also have an essential role in the regulation of the stress response and in cell adaptation to injury. Preclinical studies have suggested potential benefits of carbon monoxide in cardiovascular disease, inflammatory disorders, as well as organ transplantation [A32731].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
27.99
Hydrogen Bond Acceptors
0
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.04
TPSA
19.9
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
0.0
QED
0.26
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data