General
Preferred name
PD039100
Synonyms
P&D ID
PD039100
Tags
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
TOXICITY Cardiac toxicity, specifically QT prolongation (irregular heartbeat; recurrent fainting). ; Cholestatic hepatitis (abdominal pain; nausea; vomiting; yellow eyes or skin). ; Gastrointestinal toxicity, specifically acute colitis (abdominal pain and tenderness; bloody stools; fever). ; Intestinal injury (abdominal pain and tenderness).; Ulcerated esophagitis (chest pain; heartburn).;
HALF-LIFE Intravenous:; Young persons (18 to 32 years of age): Approximately 4.5 to 6.2 hours.; Elderly persons (73 to 85 years of age): Approximately 9.8 to 13.5 hours. ; ; Oral: 5.5-8 hours, Rectal in children: 8 hours;
ABSORPTION The extent of absorption of Spiramycin was shown to be incomplete. Oral bioavailability ranges from 30-39%. ; Spiramycin has slower rate of absorption than Erythromycin. It has a high pKa (7.9) which could be a result of high degree of ionization in acidic medium of the stomach.
Compound Sets
1
Other bioactive compounds
External IDs
10
Properties
(calculated by RDKit )
Molecular Weight
842.51
Hydrogen Bond Acceptors
16
Hydrogen Bond Donors
4
Rotatable Bonds
11
Ring Count
4
Aromatic Ring Count
0
cLogP
2.33
TPSA
195.38
Fraction CSP3
0.86
Chiral centers
19.0
Largest ring
16.0
QED
0.17
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data