General
Preferred name
CHELERYTHRINE
Synonyms
CHELERYTHRINE CHLORIDE ()
Chelerythrinechloride ()
Toddalin ()
Cheleritrine ()
Broussonpapyrine ()
Chelerythrine (chloride) ()
Chelerythrine Chloride (NSC 646662) ()
Broussonpapyrine chloride ()
Toddaline, Broussonpapyrine ()
Chelerythrine ()
P&D ID
PD038954
CAS
3895-92-9
34316-15-9
Tags
obsolete probe
nuisance
covalent binder
probe
natural product
drug candidate
available
Drug indication
Discovery agent
Drug Status
investigational
Probe info
Probe selectivity
protein-selective
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Chelerythrine is a potent, selective, and cell-permeable protein kinase C inhibitor.
(GtoPdb)
DESCRIPTION
Cdk inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
PKC inhibitor; affects translocation of PKC from cytosol to plasma membrane
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
9
Organisms
4
Compound Sets
22
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CovBinderInPDB
DrugBank
DrugMAP
DrugMatrix
Guide to Pharmacology
LINCS compound set
LOPAC library
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Nuisance compounds in cellular assays
Obsolete Compounds
Probe Miner (suitable probes)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
47
Molecular Weight
348.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
5
Aromatic Ring Count
4
cLogP
3.72
TPSA
40.8
Fraction CSP3
0.19
Chiral centers
0.0
Largest ring
6.0
QED
0.41
Structural alerts
2
historic compounds (Chemical Probes.org)
Obsolete
Nonspecific/NOS
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Selectivity
PKC
Pathway
Cytoskeletal Signaling
TGF-beta/Smad
Epigenetics
Primary Target
Protein Kinase C
MOA
PKC inhibitor
Inhibitor
Bcl-xl Inhibitors
P2X7 Receptor Antagonists
Apoptosis Inducers
Rho GTPase Inhibitors
Protein Kinase C (PKC) Inhibitors
Target
Apoptosis
Autophagy
Bcl-2 Family
Bcl-2,PKC
Member status
member
Source data
