General
Preferred name
CGP74514A
Synonyms
CGP 74514 dihydrochloride ()
CGP-74514A hydrochloride ()
CGP-74514 ()
CGP 74514A (hydrochloride) ()
P&D ID
PD038912
CAS
190653-73-7
481724-82-7
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
CGP74514A was originally reported as a CDK1 inhibitor , however later studies have identified more potent inhibitory activity against CDK2 and CDK5 and at least some inhibition of CDKs 4, 7 and 9 . This latter experimental evidence suggests that researchers should consider CGP74514A as a pan-CDK inhibitor, in acknowledgement of its promiscuous selectivity profile.
(GtoPdb)
DESCRIPTION
Cdk1 inhibitor
(LOPAC library)
DESCRIPTION
CGP 74514 Dihydrochloride is a potent cdk1 inhibitor with IC50 of 25 nM. It can reduce Akt phosphorylation and increase mitochondrial damage in leukemia cells.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Potent renin inhibitor; antihypertensive
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent cdk1 inhibitor
(Tocriscreen Plus)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
5
Organisms
1
Compound Sets
11
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
LINCS compound set
LOPAC library
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
385.18
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
3.93
TPSA
93.68
Fraction CSP3
0.42
Chiral centers
2.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
CDK
CDK1
Target Type
Enzymes
Selectivity
Cdk1
Primary Target
Cyclin-Dependent Protein Kinases
MOA
Inhibitor
CDK inhibitor
Pathway
Cell Cycle/DNA Damage
Source data
