General
Preferred name
RO-3
Synonyms
RO3 ()
P&D ID
PD038639
CAS
1026582-88-6
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION RO-3 is a potent, CNS-penetrant, and orally active P2X3 and P2X2/3 antagonist with pIC50s of 5.9 and 7.0 for human homomultimeric P2X3 and heteromultimeric P2X2/3 receptors, respectively. RO-3 shows selectivity for P2X3 and P2X2/3 over all other functional homomultimeric P2X receptors (IC50 >10 ¦ÌM at P2X1,2,4,5,7)[1].
PRICE 128
DESCRIPTION Na+ channel blocker (Tocris Bioactive Compound Library)
DESCRIPTION Selective P2X3 and P2X2/3 antagonist (Tocriscreen Plus)
DESCRIPTION RO-3 is a selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively). RO-3 is used in a combination of compounds to develop a substance used for alleviating pain and skin disorders. (BOC Sciences Bioactive Compounds)
DESCRIPTION RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor (TargetMol Bioactive Compound Library)
Compound Sets
9
BOC Sciences Bioactive Compounds
ro-3-cas-1026582-88-6-item-170281
Cayman Chemical Bioactives
29635
Drug Repurposing Hub
DrugMAP
DMRYNJE
Guide to Pharmacology
4298
MedChem Express Bioactive Compound Library
HY-19978
TargetMol Bioactive Compound Library
T5513
Tocris Bioactive Compound Library
3052
Tocriscreen Plus
3052
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
302.17
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
2.37
TPSA
96.28
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Target
P2X3
P2RX3
P2X Receptor
Primary Target
Purinergic (P2X) Receptors
MOA
Antagonist
purinergic receptor antagonist
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Source data