General
Preferred name
rac BHFF
Synonyms
(R,S)-BHFF ()
rac-BHFF ()
rac-BHFF ()
P&D ID
PD038600
CAS
123557-91-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION rac-BHFF is a potent and orally active allosteric enhancer of GABAB receptor[1].
PRICE 68
DESCRIPTION Positive allosteric modulator of the GABAB receptor. (GtoPdb)
DESCRIPTION BHFF is a positive allosteric modulator of GABAB receptor that increases the potency and efficacy of GABA. BHFF displays anxiolytic activity in vivo. (BOC Sciences Bioactive Compounds)
DESCRIPTION Potent, selective GABAB positive allosteric modulator (Tocriscreen Plus)
DESCRIPTION rac-BHFF ((R,S)-BHFF) is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). It exhibits anxiolytic activity in vivo and is orally active. (TargetMol Bioactive Compound Library)
DESCRIPTION High affinity 5-HT6 antagonist (Tocris Bioactive Compound Library)
Compound Sets
10
BOC Sciences Bioactive Compounds
rac-bhff-cas-123557-91-5-item-272024
Cayman Chemical Bioactives
25535
Concise Guide to Pharmacology 2019/20
10267
Concise Guide to Pharmacology 2021/22
10267
Concise Guide to Pharmacology 2023/24
10267
Guide to Pharmacology
10267
MedChem Express Bioactive Compound Library
HY-103519
TargetMol Bioactive Compound Library
T4176
Tocris Bioactive Compound Library
3313
Tocriscreen Plus
3313
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
330.14
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
1
cLogP
3.95
TPSA
46.53
Fraction CSP3
0.59
Chiral centers
1.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
GABAB
GABA Receptor
Primary Target
GABAB Receptors
MOA
Modulator
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Neuroscience
Source data