General
Preferred name
BMS-5
Synonyms
LIMKi 3 ()
BMS5 ()
LIMKi3 ()
P&D ID
PD038518
CAS
1338247-35-0
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Potent LIM kinase inhibitor.
(GtoPdb)
DESCRIPTION
BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.
PRICE
111
DESCRIPTION
Potent and selective Mps1 kinase inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent LIM kinase inhibitor; antitumor
(Tocriscreen Plus)
DESCRIPTION
BMS-5, a LIMK inhibitor, has been found to restrain the cofilin phosphorylation in MDA-MB-231 breast cancer cells.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
LIMKi 3 is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.
(Enamine Bioactive Compounds)
DESCRIPTION
BMS-5 (LIMKi 3) is a highly potent LIMK inhibitor, exhibiting IC50 values of 7 nM for LIMK1 and 8 nM for LIMK2.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
14
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
15
Molecular Weight
430.02
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
5.83
TPSA
59.81
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
LIM kinase (LIMK)
LIMK1
LIMK2
LIM kinase
Primary Target
LIMK
MOA
LIM Kinase
Inhibitor
LIM kinase-1 inhibitor
LIM kinase-2 inhibitor
LIM Kinase inhibitor
Member status
member
Pathway
Cell Cycle/Checkpoint
Cell Cycle/DNA Damage
Solubility
Soluble in Chloroform (Slightly), DMSO (Slightly)
Recommended Cell Concentration
1 uM
Source data
