General
Preferred name
TANDOSPIRONE HYDROCHLORIDE
Synonyms
Metanopirone ()
P&D ID
PD038433
CAS
99095-10-0
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tandospirone hydrochloride is a 5-HT1A receptor partial agonist (Ki = 27 nM) with selectivity over 5-HT2, 5-HT1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300 - 41000 nM). Tandospirone is inactive at 5-HT uptake sites, 5-HT1B, β-adrenergic, muscarinic and benzodiazepine receptors. Tandospirone is used in the treatment of anxiety and depression.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Selective 5-HT1A partial agonist
(Tocriscreen Plus)
DESCRIPTION
5-HT2A antagonist; also D2 antagonist; atypical antipsychotic
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
BOC Sciences Bioactive Compounds
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
11
Molecular Weight
419.21
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
5
Aromatic Ring Count
1
cLogP
1.83
TPSA
69.64
Fraction CSP3
0.71
Chiral centers
4.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Primary Target
5-HT1A Receptors
MOA
Agonist
Source data
