General
Preferred name
PD 166285 dihydrochloride
Synonyms
PD-166285 ()
Heparin-Cantithrombin III ()
PD-0166285 HYDROCHLORIDE ()
Pd-0166285 dihydrochloride ()
P&D ID
PD038419
CAS
212391-63-4
Tags
drug candidate
available
Drug indication
Discovery agent
Drug Status
investigational
Max Phase
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PD 166285, a novel protein tyrosine kinase inhibitor of a new structural class, is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1), and PDGFRβ (platelet-derived growth factor receptor β) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). PD 166285 also inhibits the checkpoint kinases Wee1 and MYT1 (Myt1), abolishes Cdc2 phosphorylation in numerous tumor cell lines, and abrogates the G2 checkpoint. (BOC Sciences Bioactive Compounds)
DESCRIPTION Potent Src inhibitor; also inhibits FGFR1, PDGFRbeta and Wee1 (Tocriscreen Plus)
DESCRIPTION Selective TrioN RhoGEF activity inhibitor (Tocris Bioactive Compound Library)
Compound Sets
7
AdooQ Bioactive Compound Library
A13868
BOC Sciences Bioactive Compounds
pd-166285-dihydrochloride-cas-212391-63-4-item-102058
ChEMBL Drugs
CHEMBL3545196
CZ-OPENSCREEN Bioactive Library
DrugMAP
DM7U491
Tocris Bioactive Compound Library
3785
Tocriscreen Plus
3785
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
583.11
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
4
cLogP
6.61
TPSA
72.28
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.24
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Primary Target
Src Kinases
MOA
Inhibitor
Solubility
DMSO to 100 mM
Source data