General
Preferred name
MM 11253
Synonyms
MM-11253 ()
MM11253 ()
MM-11253 ()
P&D ID
PD038414
CAS
345952-44-5
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
MM11253 is a potent and selective RAR¦Ã antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RAR¦Á, RAR¦Â and RXR¦Á. MM11253 blocks the growth inhibitory effects of RAR¦Ã-selective agonists[1][3].
PRICE
120
DESCRIPTION
MM 11253 is a RAR?? antagonist with IC50 of 44nM.
DESCRIPTION
Selective RARalpha antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
RARgamma-selective antagonist
(Tocriscreen Plus)
DESCRIPTION
MM 11253 is a RARγ antagonist. It can block the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
MM 11253 is a RARγ antagonist with IC50 of 44nM.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
17
Molecular Weight
462.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
5
Aromatic Ring Count
3
cLogP
7.57
TPSA
37.3
Fraction CSP3
0.39
Chiral centers
0.0
Largest ring
6.0
QED
0.44
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Target
RARγ
RARG
RAR/RXR
Primary Target
Retinoic Acid Receptors
MOA
Antagonist
Retinoid Receptor antagonist
Pathway
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Metabolism
Source data
