General
Preferred name
TC-FPR 43
Synonyms
pyrazolone, 1 ()
FPR Agonist 43 ()
P&D ID
PD038314
CAS
903895-98-7
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Potent FPR2 agonist (Tocriscreen Plus)
DESCRIPTION Potent non-peptide oxytocin receptor partial agonist; also V1a receptor antagonist (Tocris Bioactive Compound Library)
DESCRIPTION TC-FPR 43 is a potent formyl peptide receptor 2 (FPR2) agonist (EC50 = 44 nM) that inhibits fMLP- and IL-8-induced neutrophil migration and induces calcium mobilization. TC-FPR 43 was shown to suppress inflammation in a mouse model of acute inflammation. It also acts as an ALX agonist. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
0
Compound Sets
12
BOC Sciences Bioactive Compounds
tc-fpr-43-cas-903895-98-7-item-170478
Cayman Chemical Bioactives
29804
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMLFQKU
EU-OPENSCREEN Bioactive Compound Library
EOS100397
EUbOPEN Chemogenomics Library
EUB0000794
Guide to Pharmacology
5831
MedChem Express Bioactive Compound Library
HY-19574
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
4624
Tocriscreen Plus
4624
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
384.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
3
cLogP
4.6
TPSA
68.06
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Primary Target
Formyl Peptide Receptors
MOA
Agonist
FPR1 agonist
FPR2 agonist
formyl peptide receptor agonist
Member status
member
Target
FPR2
formyl peptide receptor (FPR)
Pathway
GPCR/G protein
Recommended Cell Concentration
None
Source data