General
Preferred name
TC LPA5 4
Synonyms
TCLPA5 ()
P&D ID
PD038286
CAS
1393814-38-4
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
TCLPA5 is a selective, non-lipid lysophosphatidic acid 5 (LPA5) receptor selective antagonist .
(GtoPdb)
DESCRIPTION
TC LPA5 4 is a LPA5 (GPR92)-specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA5-RH7777 cell line) with an IC50 of 800 nM. TC LPA5 4 displays selectivity for LPA5 over 80 other screened agent targets[1]. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells[2].
PRICE
172
DESCRIPTION
Long-acting beta2 agonist; bronchodilator
(Tocris Bioactive Compound Library)
DESCRIPTION
LPA5 receptor antagonist
(Tocriscreen Plus)
DESCRIPTION
TC LPA5 4 is a LPA5 receptor antagonist (IC50 = 0.8 μM in LPA5-RH7777 cells), displaying selectivity for LPA5 against 80 other screened targets. TC LPA5 4 was shown to inhibit LPA-induced aggregation of isolated human platelets.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
TC LPA5 4 is a LPA5 receptor antagonist.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
Guide to Pharmacology
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
12
Molecular Weight
410.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
5.95
TPSA
64.35
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
LPA5
LPAR5
LPL Receptor
Primary Target
Lysophosphatidic Acid Receptors
MOA
Antagonist
lysophosphatidic acid receptor antagonist
Pathway
GPCR/G protein
Source data
