General
Preferred name
NS 11021
Synonyms
NS11021 ()
NS-11021 ()
P&D ID
PD038261
CAS
956014-19-0
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
NS11021 activates KCa1.1 (KCNMA1) channels , by modulating gating kinetics (increasing the open probability) rather than altering single channel conductance. It is used as a tool compound for investigating the physiological and pathophysiological roles of KCa1.1 channels . NS11021 has more potent activating effect on KCa1.1 channels than .
(GtoPdb)
DESCRIPTION
NS 11021 is a potent and specific Ca2+-activated big-conductance K+ Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 ¦ÌM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials[1].
PRICE
165
DESCRIPTION
Non-competitive and GluN2C/GluN2D-selective NMDA antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Activator of BKCa (KCa1.1) channels
(Tocriscreen Plus)
DESCRIPTION
NS 11021 is an activator of large-conductance Ca2+-activated potassium channels. It has been shown to relax intracavernous arterial rings and corpus cavernosum strips in vitro.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
NS 11021 (NS11021) , a novel opener of large-conductance Ca(2+)-activated K(+) channels
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
Guide to Pharmacology
JUMP-Target 1 Compound Set
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
509.97
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
5.48
TPSA
78.52
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Target
Potassium Channel
KCNMA1
Primary Target
Calcium-Activated Potassium (KCa) Channels
MOA
Activator
calcium-activated potassium channel activator
Pathway
Membrane Transporter/Ion Channel
Source data
