General
Preferred name
NS 9283
Synonyms
NS-9283 ()
NS9283 ()
P&D ID
PD038190
CAS
913830-15-6
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
NS9283 is a positive positive allosteric modulator of (¦Á4)3(¦Â2)2 nicotinic ACh receptors. NS9283 can be used in a series of neurological conditions such as attention deficit hyperactivity disorder (ADHD), schizophrenia, Parkinson's disease and Alzheimer's disease[1].
PRICE
96
DESCRIPTION
NS9283, a positive allosteric modulator selective for the ??4??2 form, reduces ethanol consumption.
DESCRIPTION
TRPM3 blocker
(Tocris Bioactive Compound Library)
DESCRIPTION
Positive allosteric modulator of alpha4beta2
(Tocriscreen Plus)
DESCRIPTION
NS 9283 is an allosteric modulator of α4β2 receptor affecting the potency of acetylcholine related events. It can reduce the rate of recovery from desensitization and slow the rate of deactivation.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
NS 9283 is a positive allosteric modulator of α4β2 subunit-containing nicotinic acetylcholine receptors.
(Enamine Bioactive Compounds)
DESCRIPTION
NS9283, a positive allosteric modulator selective for the α4β2 form, reduces ethanol consumption.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
Enamine Bioactive Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
16
Molecular Weight
248.07
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
2.67
TPSA
75.6
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Target
α4β2 nAChR
CHRNA4
nAChR
Primary Target
Nicotinic (?4?2) Receptors
MOA
Modulator
acetylcholine receptor allosteric modulator
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data
