General
Preferred name
VERUBULIN HYDROCHLORIDE
Synonyms
MPC 6827 hydrochloride ()
MPC-6827 hydrochloride ()
Verubulin (hydrochloride) ()
MPC-6827 (hydrochloride) ()
MPC-6827 ()
Verubulin hcl ()
Azixa ()
P&D ID
PD038171
CAS
917369-31-4
Tags
available
drug candidate
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Verubulin hydrochloride (MPC-6827 hydrochloride) is a blood brain barrier permeable microtubule-disrupting agent, with potent and broad-spectrum in vitro and in vivo cytotoxic activities. Verubulin hydrochloride (MPC-6827 hydrochloride) exhibits potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models. Verubulin hydrochloride (MPC 6827 hydrochloride) is a promising candidate for the treatment of multiple cancer types[1][2].
PRICE
52
DESCRIPTION
Inhibitor of microtubule polymerization; antimitotic and antitumor
(Tocriscreen Plus)
DESCRIPTION
Verubulin hydrochloride (MPC-6827 hydrochloride) is a blood-brain barrier permeable microtubule-disrupting agent with potent and broad-spectrum cytotoxic activities and significant anticancer efficacy in human MX-1 breast cancer and various mouse xenograft cancer models.
(TargetMol Bioactive Compound Library)
DESCRIPTION
High affinity and selective HIF-2alpha inhibitor
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
Cayman Chemical Bioactives
ChEMBL Drugs
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
14
Molecular Weight
315.11
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
4.14
TPSA
38.25
Fraction CSP3
0.18
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Microtubule/Tubulin
Microtubule
Microtubule Associated
Target Type
Cell Biology
Primary Target
Microtubules
Pathway
Cell Cycle/DNA Damage
cytoskeleton
Cytoskeletal Signaling
Source data
