General
Preferred name
KT182
Synonyms
ML225 Analog ()
ML295 Analog ()
ML296 Analog ()
KT 182 ()
P&D ID
PD036268
CAS
1402612-62-7
Tags
available
covalent binder
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION KT182 is a potent and selective inhibitor of ¦Á/¦Â-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.24 nM in Neuro2A cells[1].
PRICE 130
DESCRIPTION KT182 is a selective and ?potent inhibitor of ??/??-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.24 nM in Neuro2A cells.
DESCRIPTION KT182 is a potent inhibitor of α/β-hydrolase domain-containing protein 6 (ABHD6). ABHD6 is a transmembrane serine hydrolase hydrolyzing transmembrane serine hydrolase in nernous system. ABHD6 inhibition was shown to decrease seizure incidence in several mouse models of epilepsy, suggesting its potential for Dravet Syndrome treatment. (BOC Sciences Bioactive Compounds)
DESCRIPTION KT182 is a selective and  potent inhibitor of α/β-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.24 nM in Neuro2A cells. (TargetMol Bioactive Compound Library)
DESCRIPTION Selective neutral sphingomyelin phosphodiesterase (N-SMase) inhibitor (Tocris Bioactive Compound Library)
Compound Sets
8
BOC Sciences Bioactive Compounds
kt182-cas-1402612-62-7-291391
Cayman Chemical Bioactives
15404
CovalentInDB
CI003448
EUbOPEN Chemogenomics Library
EUB0002616
MedChem Express Bioactive Compound Library
HY-120177
MLSMR Probes +
TargetMol Bioactive Compound Library
T11784
Tocris Bioactive Compound Library
6738
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
438.21
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
4
cLogP
5.3
TPSA
71.25
Fraction CSP3
0.22
Chiral centers
1.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Classification
probe analog
Target
MAGL
ABHD6
Primary Target
Other Hydrolases
MOA
Inhibitor
Pathway
Metabolic Enzyme/Protease
Metabolism
Recommended Cell Concentration
None
Source data