General
Preferred name
THIACLOPRID
Synonyms
P&D ID
PD036072
CAS
111988-49-9
1119449-18-1
Tags
available
drug candidate
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Thiacloprid, a chloronicotinyl insecticide, is targeted chiefly to control aphid pest species in orchards and vegetables[1]. Thiacloprid destabilizes DNA. Thiacloprid changes the structure and stability of DNA through binding into the minor groove by hydrophobic or hydrogen interactions[2].
PRICE 29
DESCRIPTION Thiacloprid, a chloronicotinyl insecticide, acts as a selective agonist at insect nAChRs. The IC50 values are 2.7 and 860 nM for Drosophilan AChRs and M10 mouse fibroblast cells expressing ??4??2 subunit-containing nAChRs, respectively.
DESCRIPTION Thiacloprid, a chloronicotinyl insecticide, acts as a selective agonist at insect nAChRs. The IC50 values are 2.7 and 860 nM for Drosophilan AChRs and M10 mouse fibroblast cells expressing α4β2 subunit-containing nAChRs, respectively. (TargetMol Bioactive Compound Library)
DESCRIPTION Thiacloprid is an agonist of Estrogen receptor (Enamine Bioactive Compounds)
Compound Sets
5
Cayman Chemical Bioactives
25824
DrugBank
DB08620
Enamine Bioactive Compounds
EBC-104039
MedChem Express Bioactive Compound Library
HY-B1953
TargetMol Bioactive Compound Library
T38272
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
252.02
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
2.12
TPSA
52.28
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Parasite
α4β2 nAChR
DNA Stain
Pathway
Microbiology/virology
Neuroscience
Anti-infection
Cell Cycle/DNA Damage
Source data