General
Preferred name
L-694,247
Synonyms
ICX5601627 ()
L694247 ()
L694,247 ()
L 694,247 ()
L-694247 ()
L-694,247 (trifluoroacetate salt) ()
P&D ID
PD035704
CAS
137403-12-4
Tags
available
drug candidate
Drug indication
Migraine
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
405
DESCRIPTION
5-HT1D agonist
(Tocriscreen Total)
DESCRIPTION
L-694,247 is a highly selective and extremely potent 5-HT1D receptor agonist.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
L-694,247 is a selective 5-HT receptor agonist with affinity for 5-HT1D, 5-HT1A, 5-HT1B, 5-HT1C, and 5-HT1E receptors, and can be used to study neurological diseases.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
13
BOC Sciences Bioactive Compounds
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
DrugMatrix
Guide to Pharmacology
NIH Clinical Collections (NCC)
TargetMol Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
411.14
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
4
cLogP
2.68
TPSA
126.9
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT
HTR1A, HTR1B, HTR1D
MOA
serotonin receptor agonist
Pathway
GPCR/G protein
Neuroscience
Source data
