General
Preferred name
PD 102807
Synonyms
CHEMBL59898 ()
P&D ID
PD035687
CAS
23062-91-1
Tags
available
probe
Probe info
Probe type
calculated probe
Probe sources
Tool Compound Set
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PD 102807 is a M4 muscarinic receptor antagonist with an IC50 of 90.7 nM. PD 102807 inhibits M1, M2, M3, M5 muscarinic receptor with IC50s of 6558.7, 3440.7, 950.0, and 7411.7 nM, respectively[1]. Antidyskinetic effect.
DESCRIPTION PD 102807 is a selective mAChR M4 antagonist with IC50 values of 91, 6559, 3441, 95 and 7412 nM for human M4, M1, M2, M3, and M5 receptors respectively. (BOC Sciences Bioactive Compounds)
DESCRIPTION Selective M4 antagonist (Tocriscreen Plus)
DESCRIPTION Selective M4 antagonist (Tocriscreen Total)
DESCRIPTION Potent and selective D1 antagonist (Tocris Bioactive Compound Library)
Compound Sets
11
BOC Sciences Bioactive Compounds
pd-102807-cas-23062-91-1-item-77117
Concise Guide to Pharmacology 2021/22
11498
Concise Guide to Pharmacology 2023/24
11498
CZ-OPENSCREEN Bioactive Library
EUbOPEN Chemogenomics Library
EUB0000414
Guide to Pharmacology
11498
MedChem Express Bioactive Compound Library
HY-107646
Tocris Bioactive Compound Library
1671
Tocriscreen Plus
1671
Tocriscreen Total
Tool Compound Set
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
392.17
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
5
Aromatic Ring Count
3
cLogP
4.11
TPSA
63.79
Fraction CSP3
0.35
Chiral centers
1.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
Muscarinic acetylcholine receptor M4
mAChR
Primary Target
M4 Receptors
MOA
Antagonist
Pathway
GPCR/G protein
Neuronal Signaling
Recommended Cell Concentration
10 uM
Source data