General
Preferred name
CCT 031374 hydrobromide
Synonyms
CCT031374 (hydrobromide) ()
P&D ID
PD032859
CAS
1219184-91-4
442535-46-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION CCT 031374 hydrobromid is a potent inhibitor of ¦Â-catenin/transcription factor (TCF) complex signaling. CCT031374 inhibits TCF-dependent transcription of genes of Wnt signaling pathway. CCT 031374 has antitumor activity[1].
PRICE 95
DESCRIPTION CCT 031374 hydrobromide is a TCF/??-catenin inhibitor with antitumor activities.
DESCRIPTION Cryptochrome protein stabilizer; lengthens circadian period (Tocris Bioactive Compound Library)
DESCRIPTION Inhibits TCF-dependent transcription; lowers beta-catenin levels (Tocriscreen Plus)
DESCRIPTION CCT 031374 hydrobromide is an inhibitor of TCF-dependent transcription. It was shown to block BIO-induced β-catenin stabilization, and reduce nuclear and cytosolic β-catenin levels in mouse L-cells. (BOC Sciences Bioactive Compounds)
DESCRIPTION CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
0
Compound Sets
8
Axon Medchem Screening Library
2161
BOC Sciences Bioactive Compounds
cct-031374-hydrobromide-cas-1219184-91-4-item-119000
Cayman Chemical Bioactives
32866
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
HY-108441
TargetMol Bioactive Compound Library
T21685
Tocris Bioactive Compound Library
4675
Tocriscreen Plus
4675
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
353.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
3
cLogP
4.23
TPSA
35.91
Fraction CSP3
0.13
Chiral centers
0.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Target
TCF/β-catenin
CTNNB1
Wnt inhibitor
¦Â-catenin
Wnt
β-catenin
Primary Target
?-catenin
MOA
WNT signaling inhibitor
Pathway
Stem Cell/Wnt
Cytoskeletal Signaling
Stem Cells
Source data