General
Preferred name
FURAMIDINE
Synonyms
Furamidine dihydrochloride ()
Furamidine (dihydrochloride) ()
DB75 (dihydrochloride) ()
NSC 305831 (dihydrochloride) ()
Furamidine (hydrochloride) ()
DB75 ()
DB-75 ()
NSC-305831 ()
P&D ID
PD032605
CAS
73819-26-8
55368-40-6
Tags
available
probe
drug candidate
Probe info
Probe type
calculated probe
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
1
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 ¦ÌM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 ¦ÌM, 283 ¦ÌM, and >400 ¦ÌM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent[1][2][3].
DESCRIPTION
Potent and selective MAGL inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective PRMT1 inhibitor
(Tocriscreen Plus)
DESCRIPTION
Furamidine dihydrochloride is a protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 9.4 μM) in the class of antimicrobial and antiparasitic agents. It was shown to inhibit cell proliferation in leukemia cell lines.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
5
Organisms
8
Compound Sets
9
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Probe Miner (suitable probes)
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
30
Molecular Weight
304.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
3
cLogP
3.18
TPSA
112.88
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.44
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Primary Target
Protein Arginine Methyltransferases
MOA
Inhibitor
Protein Arginine N-Methyltransferase 1 (PRMT1) Inhibitors
Antimalarial
reverse mis-splicing in Myotonic dystrophy type 1 (DM1)
protein arginine N-methyltransferase inhibitor
Member status
virtual
Target
PRMT1
Histone methyltransferase
Parasite
Phosphodiesterase (PDE)
Pathway
Anti-infection
Epigenetics
Metabolic Enzyme/Protease
Source data
