General
Preferred name
EPRINOMECTIN
Synonyms
MK-397 ()
EPM, MK-397 ()
Eprinomectin B1a ()
P&D ID
PD029347
CAS
123997-26-2
133305-88-1
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Eprinomectin (MK-397) is a type of avermectin. Eprinomectin, as a broad-spectrum fungicide, has insecticidal, insecticidal and acaricidal activities. Eprinomectin induces apoptosis and autophagy in prostate cancer cells and has antitumor activity[1][2][3].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
Cayman Chemical Bioactives
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
Other bioactive compounds
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
68
Molecular Weight
913.52
Hydrogen Bond Acceptors
14
Hydrogen Bond Donors
3
Rotatable Bonds
9
Ring Count
7
Aromatic Ring Count
0
cLogP
5.52
TPSA
178.93
Fraction CSP3
0.76
Chiral centers
20.0
Largest ring
16.0
QED
0.19
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
gastrointestinal roundworms, lungworms
MOA
benzodiazepine receptor agonist
Target
Apoptosis
Autophagy
Bacterial
Parasite
Reactive Oxygen Species (ROS)
β-catenin
Reactive Oxygen Species
¦Â-catenin
Pathway
Anti-infection
Immunology/Inflammation
Metabolic Enzyme/Protease
NF-κB
Stem Cell/Wnt
NF-¦ÊB
Source data
