General
Preferred name
NAVARIXIN
Synonyms
MK-7123 ()
SCH 527123 ()
SCH-527123 ()
MK-7123, PS-291822 ()
Navarixin (SCH-527123) ()
NAVARIXIN ANHYDROUS ()
SCH527123 ()
Navarixin (anhydrous) ()
Navarixina ()
Navarixine ()
MK7123 ()
PS-291822 ()
SCH-527123 MONOHYDRATE ()
PS291822 ()
Navarixin monohydrate ()
MK-7123 MONOHYDRATE ()
P&D ID
PD022859
CAS
473727-83-2
Tags
available
drug candidate
Drug indication
Chronic obstructive pulmonary disease
Solid tumour/cancer
Inflammatory bowel disease
Ulcerative colitis
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Navarixin (SCH-527123) is a potent and orally bioavailable CXCR2/CXCR1 receptor antagonist .
DESCRIPTION Navarixin (SCH-527123, MK-7123) is a potent and orally bioavailable CXCR2/CXCR1 receptor antagonist . (GtoPdb)
DESCRIPTION Navarixin (SCH 527123) is a potent, allosteric and orally active antagonist of both CXCR1 and CXCR2, with Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectivelly[1][2].
PRICE 104
DESCRIPTION Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be beneficial in the treatment of conditions with unbalanced pulmonary neutrophilia. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
18
Cayman Chemical Bioactives
27800
ChEMBL Drugs
CHEMBL216981
CHEMBL2103864
Concise Guide to Pharmacology 2017/18
8497
Concise Guide to Pharmacology 2019/20
8497
Concise Guide to Pharmacology 2021/22
8497
Concise Guide to Pharmacology 2023/24
8497
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMPUAOE
EU-OPENSCREEN Bioactive Compound Library
EOS101476
Guide to Pharmacology
8497
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL216981
MedChem Express Bioactive Compound Library
HY-10198
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
sch-527123
TargetMol Bioactive Compound Library
T7130
ZINC Tool Compounds
ZINC000100033051
External IDs
37
Properties
(calculated by RDKit )
Molecular Weight
397.16
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
3
cLogP
2.9
TPSA
111.88
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.42
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CXCR
CXCR1
CXCR2
CXCR1, CXCR2
Member status
member
MOA
Apoptosis Inducers
Chemokine CXCR1 (IL-8 alpha Receptor) Antagonists
Chemokine CXCR2 (IL-8 beta Receptor) Antagonists
Angiogenesis Inhibitors
CC chemokine receptor antagonist
Pathway
Autophagy
GPCR/G protein
Immunology/Inflammation
Source data