General
Preferred name
(-)-Bicuculline methochloride
Synonyms
N-methylbicuculline ()
Bicuculline (methochloride) ()
(-)-Bicuculline (methochloride) ()
l-Bicuculline (methochloride) ()
P&D ID
PD022030
CAS
38641-83-7
Tags
drug candidate
available
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Bicuculline ((+)-Bicuculline; d-Bicuculline) methochloride is a selective GABAA receptor antagonist with an IC50 value of 3 ¦ÌM. Bicuculline methochloride induces clonic tonic convulsions in mammals and can also be used to block Ca2+ activated potassium channels. Bicuculline methochloride can be used in studies of epilepsy and other related psychiatric disorders[1][2].
DESCRIPTION Water-soluble GABAA antagonist (Tocriscreen Total)
DESCRIPTION Selective AMPA agonist (Tocris Bioactive Compound Library)
Compound Sets
4
DrugMAP
DM5GXIS
MedChem Express Bioactive Compound Library
HY-137790
Tocris Bioactive Compound Library
0131
Tocriscreen Total
External IDs
14
Properties
(calculated by RDKit )
Molecular Weight
417.1
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
6
Aromatic Ring Count
2
cLogP
-0.27
TPSA
63.22
Fraction CSP3
0.38
Chiral centers
2.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
GABAA Receptors
MOA
Antagonist
Target
GABA Receptor
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data