General
Preferred name
PD022025
Synonyms
7-CHLOROKYNURENIC ACID ()
7-Chlorokynurenic acid sodium salt ()
7-Chlorokynurenic acid (sodium salt) ()
7-CKA ()
7-CKA (sodium salt) ()
Kynurenic acid, 7-chloro- ()
NSC-149792 ()
P&D ID
PD022025
CAS
18000-24-3
1263094-00-3
Tags
drug candidate
natural product
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent competitive inhibitor of L-glutamate uptake
(Tocriscreen Plus)
DESCRIPTION
Potent competitive inhibitor of L-glutamate uptake
(Tocriscreen Total)
DESCRIPTION
7-Chlorokynurenic acid is a water-soluble and very potent NMDA receptor antagonist acting at the strychnine-insensitive glycine binding site. It is also a potent competitive inhibitor of L-glutamate transport into synaptic vesicles. It is used in studies of schizophrenia and neuroprotection.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Selective MRP1 and P-gp inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
7-Chlorokynurenic acid sodium salt is the sodium salt of 7-Chlorokynurenic acid, which is a water-soluble and very potent NMDA receptor antagonist acting at the strychnine-insensitive glycine binding site with IC50 value of 0.56 µM. It is also a potent competitive inhibitor of L-glutamate transport into synaptic vesicles. It is used in studies of schizophrenia and neuroprotection.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
9
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugMatrix
MedChem Express Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
223.0
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
2
cLogP
2.29
TPSA
70.42
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Transporters
Primary Target
Glutamate (EAAT) Transporters
MOA
Inhibitor
glutamate receptor antagonist
Target
GRIN1, GRIN2A, GRIN2B, GRIN2C
iGluR
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data
