General
Preferred name
C-1
Synonyms
HA-100 ()
HA-100 dihydrochloride ()
HA-100 (hydrochloride) ()
P&D ID
PD021985
CAS
84468-24-6
210297-47-5
Tags
natural product
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Protein kinase C inhibitor (Tocriscreen Plus)
DESCRIPTION Protein kinase C inhibitor (Tocriscreen Total)
DESCRIPTION C-1 is a protein kinase inhibitor selecitive for PKG, PKA and PKC (IC50 = 4, 8 and 12 µM, respectively) and is widely used as a ROCK inhibitor. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
10
BOC Sciences Bioactive Compounds
c-1-cas-84468-24-6-item-35084
Cayman Chemical Bioactives
14955
Drug Repurposing Hub
DrugMatrix
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-100984
Selleckchem Bioactive Compound Library
ha-100
ha-100-free-base
TargetMol Bioactive Compound Library
T7648
Tocriscreen Plus
0543
Tocriscreen Total
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
277.09
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
0.83
TPSA
62.3
Fraction CSP3
0.31
Chiral centers
0.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
GPCR/G protein
Cytoskeletal Signaling
Cell Cycle/DNA Damage
cytoskeleton
Epigenetics
Stem Cell/Wnt
TGF-beta/Smad
Target
PKA
PRKCA
Myosin
PKC
ROCK
MLCK,PKA,PKC,PKG
PKG
MOA
protein kinase inhibitor
Source data