General
Preferred name
RS 23597-190 hydrochloride
Synonyms
RS 23597-190 ()
RS 39604 hydrochloride ()
EP-A-501322 ()
P&D ID
PD021949
CAS
149719-06-2
167710-87-4
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Standard H3 and H4 agonist (H3 > H4)
(Tocris Bioactive Compound Library)
DESCRIPTION
5-HT4 antagonist
(Tocriscreen Total)
DESCRIPTION
RS 23597-190 hydrochloride is a selective and competitive SR-4 and 5-HT4 receptor antagonist with in vitro and in vivo efficacy.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
RS 39604 is a high affinity and selective 5-HT4 receptor antagonist that is orally active and long-lasting in vivo, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. It is concluded that RS 39604 may be the preferable probe to use for investigating the physiological and pathophysiological role of 5-HT4 receptors in vivo.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
BOC Sciences Bioactive Compounds
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
13
Molecular Weight
362.12
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
1
cLogP
3.39
TPSA
64.79
Fraction CSP3
0.56
Chiral centers
0.0
Largest ring
6.0
QED
0.48
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
5-HT4 Receptors
MOA
Antagonist
Pathway
GPCR/G protein
Neuronal Signaling
Target
5-HT Receptor
Source data
