General
Preferred name
(S)-3,4-DCPG
Synonyms
(S)-3,4-Dicarboxyphenylglycine HCl ()
(S)-3,4-DCPG HCl(201730-11-2 Free base) ()
DCPG ()
(S)-3,4-DCPG HCl ()
DCPG ()
(S)-3,4-DCPG ()
P&D ID
PD021921
CAS
201730-11-2
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 507
DESCRIPTION Potent and selective 5-HT1B agonist (Tocris Bioactive Compound Library)
DESCRIPTION Potent, selective mGlu8a agonist (Tocriscreen Total)
DESCRIPTION DCPG is a potent and selective mGlu8a agonist (EC50 = 31 nM) displaying > 100-fold selectivity over mGlu1-7. It increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo. (BOC Sciences Bioactive Compounds)
DESCRIPTION (S)-3,4-DCPG HCl ((S)-3,4-Dicarboxyphenylglycine HCl) is a selective metabotropic glutamate receptor 8a (mGluR8a) agonist that has an effect on human mGluR8-expressing AV12-664 cells with an EC50 of 31 nM. (TargetMol Bioactive Compound Library)
Compound Sets
16
BOC Sciences Bioactive Compounds
dcpg-cas-201730-11-2-item-233115
Cayman Chemical Bioactives
22072
Concise Guide to Pharmacology 2017/18
1407
Concise Guide to Pharmacology 2019/20
1407
Concise Guide to Pharmacology 2021/22
1407
Concise Guide to Pharmacology 2023/24
1407
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMG5BUA
EUbOPEN Chemogenomics Library
EUB0000429
Guide to Pharmacology
1407
Mcule NIBR MoA Box Subset
MCULE-9728607980
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T23288L
Tocris Bioactive Compound Library
1302
Tocriscreen Total
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
239.04
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
0.17
TPSA
137.92
Fraction CSP3
0.1
Chiral centers
1.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
mGluR
GRM8
Primary Target
Glutamate (Metabotropic) Group III Receptors
MOA
Agonist
mgluR8 Agonists
glutamate receptor agonist
Member status
member
Pathway
Neuroscience
Recommended Cell Concentration
1 uM
Source data