General
Preferred name
(S)-(+)-Dimethindene maleate
Synonyms
(S)-(+)-Dimethindene (maleate) ()
P&D ID
PD021904
CAS
136152-65-3
Tags
natural product
drug
available
Drug indication
Pruritus
Drug Status
approved
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Highly selective, orally active non-peptide ETA antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
M2-selective antagonist
(Tocriscreen Total)
DESCRIPTION
The maleate salt form of (S)-(+)-Dimethindene, which has been found to be a subtype-selective mAChR M2 antagonist and histamine H1 receptor antagonist.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
BOC Sciences Bioactive Compounds
DrugMAP
DrugMAP Approved Drugs
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
9
Molecular Weight
408.2
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
3.86
TPSA
90.73
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
M2 Receptors
MOA
Antagonist
Therapeutic Class
Antiinflammatory Agents
Pathway
GPCR/G protein
Immunology/Inflammation
Neuronal Signaling
Target
Histamine Receptor
mAChR
Source data
