General
Preferred name
GLEMANSERIN
Synonyms
MDL 11,939 ()
MDL11939 ()
MDL-11939 ()
MDL 11939 ()
MDL 11939 ()
Glemanserina ()
MDL-11,939 ()
Glemanserine ()
P&D ID
PD021894
CAS
107703-78-6
Tags
available
drug candidate
Drug indication
Anxiety disorder
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Glemanserin (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively)[1][2].
PRICE
88
DESCRIPTION
The INN-assigned compound glemanserin is a racemic mixture of two enantiomers. The structure shown here does not specify stereochemistry and represents the mixture.
(GtoPdb)
DESCRIPTION
MDL 11939 is a selective 5-HT2A receptor antagonist. MDL 11939 has anti-arrhythmic activity in anesthetized dogs following myocardial infarction.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
5-HT2A antagonist
(Tocriscreen Plus)
DESCRIPTION
5-HT2A antagonist
(Tocriscreen Total)
DESCRIPTION
Glemanserin (MDL11939) is a specific 5-HT2A antagonist with Ki values of 0.54 nM, 2.5 nM and 2.89 nM for rabbit, human and rat 5-HT2A.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Selective GPR55 agonist. FAAH and PAA substrate
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
DrugMAP
DrugMatrix
Guide to Pharmacology
Ki Database
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
20
Molecular Weight
295.19
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
3.67
TPSA
23.47
Fraction CSP3
0.4
Chiral centers
1.0
Largest ring
6.0
QED
0.91
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
5-HT2A
Serotonin Transporter
Primary Target
5-HT2A Receptors
MOA
Antagonist
Pathway
Neuronal Signaling
GPCR/G protein
Neuroscience
Source data
